With the unprecedentedly growing demand for data and computation extensive Internet of Things (IoT) services, the main mission of Guangdong Provincial Key Lab of Integrated Communication, Sensing and Computation for Ubiquitous IoT is to advance research frontiers in architecture and vertical applications of ubiquitous IoT, including smart city, digital twin-based smart transportation, smart health and autonomous systems etc. The lab is also committed to developing innovative solutions for Artificial intelligence of Things (AIoT) leveraging cutting-edge technologies such as computer vision, natural language processing and artificial intelligence-generated content (AIGC). By pushing the boundaries of communication, sensing and computation towards their cross-dsiplineary synergy, the Guangdong Provincial Key Lab is at the forefront of shaping the future of ubiquitous IoT and fostering the next-generation talents in digital transformation.